Overview of Ligandrol
If you’re considering a cycle with Ligandrol or LGD-4033, then you need to know all the facts, including its mechanism of action, clinical evidence, the recommended dosage, and potential side effects. This comprehensive Ligandrol review will help you see if this performance enhancer is right for you.
The novel, oral selective androgen receptor modulator (SARM) Ligandrol is exploding in popularity among workout enthusiasts, athletes, and bodybuilders thanks to its impressive strength and potency, even when taken in lower doses. Ligandrol is one of the most potent SARMs currently out there.
What Is Ligandrol (LGD-4033)?
Ligandrol is a novel non-steroidal compound with clinical purposes i.e. used for the treatment of various bone and muscle conditions including osteoporosis, muscle wasting, and other muscle degenerative diseases. It is classified as a SARM, and it has been clinically proven to be very effective when it comes to gaining and maintaining lean muscle. This SARM is administered orally and is legal to use.
Ligandrol was discovered by San Diego, CA-based pharmaceutical company Ligand Pharma and is currently under research by Viking Therapeutics as treatment for different types of malignancies such as prostate and breast cancer. Also called Anabolicum (VK-5211), Ligandrol is anabolic in nature and, unlike anabolic steroids and even prohormones, it doesn’t have serious harmful effects on the vital organs (e.g. the kidneys and liver).
It’s worth noting that Ligandrol, as well as other SARMs with potent performance-enhancing properties, are not yet approved by the FDA because further research is still needed. Nevertheless, Ligandrol is a much safer performance enhancer than anabolic steroids, according to several clinical trials conducted so far. So if you plan on using a performance enhancer, you might as well choose a legal and safer option such as Ligandrol.
How Does Ligandrol (LGD-4033) Work?
As aforementioned, Ligandrol is a selective androgen receptor modulator (SARM), which means that it works by selectively binding androgen receptors in the bones and muscles. This makes it beneficial in both cutting and bulking. If you’re more familiar with Ostarine (MK-2866), then you should that Ligandrol works just like Ostarine, except it’s much stronger.
As opposed to anabolic steroids and prohormones which provide only half the muscle and are known for causing some serious side effects, Ligandrol offers maximum anabolic benefits with minimal androgenic effects. This is thanks to the fact that SARMs including Ligandrol doesn’t get aromatized into the dreaded estrogen. So in addition to helping you gain lean muscle mass and burn fat rapidly, it also prevents your body from retaining extra water.
I’ve personally used several SARMs and I can reassure you that Ligandrol is one of the best SARMs out there. Other users have also experienced impressive muscle mass and strength gains during a Ligandrol cycle. Expect to gain 10-15 lbs of lean muscle mass, but be sure to increase the dose slowly ( no more than 1 mg/day), especially if you’re new to Ligandrol.
Ligandrol Clinical Trial
According to this study titled “the Safety, Pharmacokinetics, and Effects of Ligandrol, a Novel Non-Steroidal Oral SARM in Healthy Young Men”, LGD-4033 binds androgen receptors with extremely high affinity and selectivity. To assess the tolerability, safety, effectiveness, and effects of Ligandrol on lean muscle mass and strength, sex hormones, and stair-climbing power, 76 healthy young men ( aged 21-50) were administered ascending doses of Ligandrol (three different doses i.e. 0.1 mg, 0.3 mg, and 1 mg were assessed against placebo) daily for 3 weeks.
The results of this clinical study conducted by scientists at Boston Medical Center suggest that Ligandrol is well-tolerated even when higher doses are administered, and no serious side effects are experienced by users. Furthermore, it suggests that lean muscle gains are dependent on the dose administered.
LGD-4033 has a long half-life, of nearly 30 hours, which means that dosing it just once per day will maintain stable Ligandrol levels throughout the entire day. Ligandrol is not only safe and effective but also convenient to use.
The Benefits of Using Ligandrol
Ligandrol is one of the most popular SARMs for a reason — it offers multiple benefits with little to no adverse effects. Let’s take a look at some of them.
- Rapid Increase in Lean Muscle Mass
True to its other name, Anabolicum, Ligandrol has outstanding anabolic capacities, and it works wonders when you’re bulking up. It packs on lean muscle quite rapidly, making it similar to Testolone (RAD-140). In addition to helping you gain size, Ligandrol also promotes muscle hardness and vascularity. Being extremely potent, both men and women experience a speedy increase in hard, lean muscle even at lower dosages.
- Massive Strength Gains
Ligandrol significantly improves your athletic performance, enabling you to train heavier and drastically increase the weights, sets, and reps. This SARM takes up to 2 weeks to fully kick in, so soon after you’ll start noticing impressive strength gains and enhanced workout intensity. As your workout sessions become more intense and longer-lasting, your body will break down significantly more muscle fibers through microtears. This helps stimulate muscle growth during the process of healing.
- Improved Recovery
During a Ligandrol cycle, you’ll be able to experience more rapid recovery. I personally swear by Ligandrol to speed up recovery which is absolutely crucial when building muscle. Be sure to get adequate rest on a daily basis. This allows you to maximize workout intensity for bigger and stronger muscles.
- Great for Maintaining Lean Muscle Mass
As discussed, Ligandrol is beneficial for cutting too, helping you maintain your muscle mass in the context of a caloric deficit. Like other versatile SARMs with lean muscle-retaining properties such as Ostarine, Ligandrol helps prevent your body from losing muscle mass during an aggressive cut.
Ligandrol (LGD-4033) Recommended Dosage
First things first, it’s essential to keep in mind that Ligandrol is a very powerful SARM that effectively works even at lower dosages and this fact is clinically proven. According to the clinical study discussed above, users are able to experience lean muscle gains when taking just 1 mg of Ligandrol, once per day.
Anecdotal evidence suggests that doses between 5 mg and 10 mg of Ligandrol per day are the most effective without compromising safety. I personally started out using only 5 mg of Ligandrol per day and gradually increased the dose, capping at 10 mg of Ligandrol per day, just to stay on the safe side.
I don’t advise you to exceed 10 mg per day for 2 main reasons:
1. You will see an impressive increase in lean muscle mass and strength with up to 10 mg, taken once a day
2. You won’t risk any serious adverse effects, such as increased testosterone suppression which may occur at doses higher than 10 mg per day.
For women, the recommended daily dose of Ligandrol is up to 5 mg.
The typical Ligandrol cycle is anywhere between 6 and 10 weeks, given the fact that up to 2 weeks are needed only for it to fully kick in. If you’re new to Ligandrol, you should advisedly use it for 6 weeks only at a lower dosage. After a break of 3-4 weeks, you can start a new Ligandrol cycle and gradually increase the dose.
After the cycle with Ligandrol, it’s recommended to use a Post-Cycle Therapy (PCT) to protect you from any potential adverse effects. This is especially true if you’re a more experienced user and you prefer to use higher doses. That’s because testosterone suppression is dose-dependent. A PCT taken for 30 days will prevent you from losing your muscle gains while restoring your testosterone levels.
Ligandrol (LGD-4033) Side Effects
When compared to anabolic steroids and even prohormones, Ligandrol and other SARMs have minimal adverse effects as long as the recommended doses are not exceeded. No serious side effects were reported by the 76 participants in the clinical trial conducted at Boston Medical Center. At doses of 10 mg per day, users have reported only some mild side effects such as light headaches, mood swings, and minor digestive issues.
It’s clinically proven that Ligandrol users experience increased lean muscle mass and strength when taking it even at lower doses. So there’s no need to take higher doses per day when lower doses work just fine and help prevent dose-dependent testosterone suppression. If after the Ligandrol cycle you’re experiencing symptoms of low testosterone e,g. fatigue, low energy levels, low sex drive, and irritability then you need to take a SARMs PCT
Ligandrol for Sale: Where to Buy Ligandrol
When shopping around for Ligandrol, you should advisedly choose to buy only from reputable and reliable SARMs suppliers such as SARMs4You, which sells SARMs exclusively, and Science.Bio. This way, you can rest assured that you get top-quality Ligandrol, tested by third-party laboratories for purity and quality. There are many companies that claim they sell the real deal but deliver prohormones instead of SARMs.
The Bottom Line
Ligandrol or LGD-4033 is one of the most effective and popular SARMs out there. Weightlifters, bodybuilders, and workout enthusiasts swear by it because it rapidly increases lean muscle mass and strength while intensifying their workout and speeding up recovery. This extremely potent performance enhancer is legal to use and offers maximum anabolic benefits in a short period of time, with minimal side effects, making it safe and effective in lower doses than Ostarine ( up to 10 mg, once per day will do the trick). Be sure to get your Ligandrol from a trusted SARMs vendor.