Cardarine (GW501516): Pro’s & con’s

Cardarine : The Complete Guide

Cardarine is often mistaken for a selective androgen receptor modulator (SARM) However, it is actually a Peroxisome proliferator-activated receptor( delta agonist) It was introduced in the mid 1990’s by pharmaceutical company Ligand Pharmaceuticals and GlaxosmithKline. The drug was initially developed as a remedy for diabetes and heart diseases. 

Some studies in 2006 and 2007 revealed that consumption of Cardarine in rats could cause cancer cell growth. However, some studies also showed a reduction in cancer cells as a result of the consumption of Cardarine. The drug itself has not been officially approved by any regulatory body however, some bodybuilders and athletes still use it to boost muscle growth and increase endurance. Despite the safety concerns, athletes have used it to strengthen the heart and improve cardiovascular performance. 

How Does Cardarine Work ? 

As stated previously, Cardarine is referred to as a  Peroxisome proliferator-activated receptor it bonds with the Peroxisome receptor to cause a reaction in the body. 

Here is what happens: 

  • Increases oxygen in the muscles which results in enhanced fat reduction 
  • Switches the body’s energy source from glucose to fat (inhibits glucose metabolism) 

One of the reasons bodybuilders and athletes like Cardarine is that it suppresses glucose metabolism. This increases energy and boosts endurance, thus increasing fitness levels. 

Another major area of interest regarding Cardarine is its possible ability to treat diabetes. With the suppression of glucose metabolism, it increases insulin sensitivity, meaning that it could potentially be used to treat the disease. 

When glucoses metabolism is inhibited, the body begins to use fat as a source of energy as opposed to the glucose obtained from food. Therefore, it could be good for people who have lots of excess fat to lose.

Benefits of Cardarine 

Some of the benefits related to taking cardarine are an increase in fat loss, more energy, enhanced endurance and cardiovascular stamina. Here is a list of possible benefits of taking Cardarine: 

Enhanced Endurance 

Some users have reported a marked improvement in their endurance after taking Cardarine for a period of time. Endurance is enhanced for the following reasons: 

  1. Inhibits glucose metabolism- the body stops using glucose as an energy source and starts using fat instead. 
  2. More oxygen flows to the muscles providing more energy and  strength.

When the body stops using glucose as an energy source, stamina and overall endurance is drastically increased. Studies have shown that when glucose metabolism is suppressed, endurance can be increased by as much as 60 percent. 

Studies undertaken where rats were given Cardarine, it took the rats who had been given Cardarine twice as long to get tired. 

Most users report noticeable differences in endurance after 30 minutes of taking the drug. Users have also reported significant changes in endurance after taking it for three or four weeks. The best way of seeing massive results with Cardarine is to cycle it for a period of time and then continue to train hard for a few weeks after you stop taking it. 

Runners for example, notice drastic results when they take Cardarine. If you are normally accustomed to running three miles a day, you should be able to run four miles without any problem at all when you take Cardarine. Some users have reported a great improvement in their breathing and overall lung capacity. 

Fat Loss 

Fat loss is one of the major benefits of Cardarine, there are two factors that cause fat loss when you take Cardarine: 

  • More oxygen to the muscles- when more oxygen gets to the muscles, the body’s ability to burn calories increases 
  • Inhibition of glucose metabolism- when the body stops using glucose as an energy source, it turns to fat. Think ketogenic or low carbohydrate diet. When the body eventually gets into ketosis mode where the body starts to utilize fat as an energy source instead of glucose (from carbohydrates) 

Cardarine users have reported rapid weight/fat loss after taking Cardarine for a period of six to eight weeks. 

Cardiovascular Strength 

Cardarine was initially introduced to help to treat cardiovascular diseases, research undertaken on rats revealed positive results pertaining to the cardiovascular system. When Cardarine was given to rats, there was an improvement in blood vessel health and there was a great reduction in inflammation too. 

Even when the dosage was reduced, there was some significant change in blood vessel health. It was also effective in reducing the accumulation of plaque in the blood vessels. 

Cardarine is often used as an antidote to the negative side effects of some steroids, which can eventually lead to cardiovascular problems. 

Liver and Kidney Health 

Unlike some high performance drugs or supplements, Cardarine does not damage the liver or the kidneys. In fact some research has shown that it actually has a positive impact on these particular organs. Studies have shown that it has a positive impact on inflammation in the kidneys and the liver. It also reduces the risk of liver or kidney disease. 

Also because it encourages the body to use fat as an energy source and enhances insulin resistance, this is great news for the liver. Also, for diabetes sufferers, this is good news. 

Cardarine Side Effects

Here are some of the possible side effects of taking Cardarine. Like most supplements or drugs out there, you should consider the possible side effects before you start taking them. 

There seems to be only one major side effect of taking Cardarine and that is: 

  • Increases cancer tumor growth and development 

In 2007, a study was carried out by GlaxoSmithKline and it found that when rats were given Cardarine and it revealed cancer tumor growth in the rats that were administered the drug. However, some researchers have stated that this study was not valid because they gave the rats large doses of the drug. In recent years, other studies have taken place that revealed different results. Some of the most recent studies revealed an overall reduction in cancer cells. 

Cardarine Dosage 

When it comes to taking Cardarine and other supplements or drugs, it is important to stick to the dosage recommendations. There have been a few clinical trials that have taken place on humans as well as rats. From some of the studies undertaken, it appears that the normal dose for a healthy adult should be Around 15-20mg per day. The cycle length should be no more than eight weeks. 

The human trials that have taken place revealed that the drug has no detrimental effect on the liver or the kidneys. In fact, the results of the trials were mostly positive. Showing a positive impact on HDL cholesterol and triglycerides. Other studies have also shown significant changes in insulin sensitivity and a marked decrease in fatty acids. 

Also, the human trials revealed that overall fat composition was reduced, and these participants were not put on a special diet, they just ate normally for a period of 12 weeks. Some of the participants were given just 10mg per day during this period. They experienced no significant side effects at all. As a result of these studies, many people prefer to take Cardarine for about 8 weeks at 10 to 15 mg per day. 


Cardarine is effective in boosting endurance and reducing fat in the body. There are no major side effects associated with taking the drug however, it is vital that you consult your doctor before taking it, especially if you are already taking some form of medication. Cardarine improves insulin sensitivity and it could be used as a potential treatment for diabetes.